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Seroquel (Quetiapine)

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Seroquel is a type of antipsychotic prescription medicine. The active agent of this drug is called Quetiapine fumarate. It is used to treat different psychotic conditions ranging from Bipolar disorders to Schizophrenia. Seroquel is sometimes called an antimanic agent.

The drug comes in different colors (peach, yellow, or white), and it’s round or oblong. The tablets are usually inscribed with "SEROQUEL" and a number representing each tablet's milligram. Thus we have Seroquel 25, Seroquel 50, Seroquel 100, Seroquel 400, etc.

How to Take Seroquel

The drug should only be taken as directed by a doctor. You will get the quantity that is needed for a specified period of time. Consuming the drug in excess or prolonged use can lead to permanent mobility disorders like tremors or uncontrolled involuntary muscular movements.

Seroquel should be taken via the mouth with copious amounts of water. It can be taken with or without food. But it is usually advised that the extended-release tablets be ingested with at least a small amount of food. Additionally, Seroquel is best taken in the evening. The tablets should not be chewed or broken; they should be consumed whole.

Dosage and Indications

For Schizophrenia:

In children between 13 to 17 years, a 400 to 800 mg dose per day is recommended. It should not exceed 800 mg per day. The patient can be administered a 5-day treatment regimen comprising 50 mg per day on the first day, which can be increased to 400 mg on the 5th day.

In adults (18 years and above), the recommended dose is 300 mg per day for five days. The dose can be adjusted as deemed fit by your doctor. It should, however, not exceed 800mg per day.

Depression with Bipolar Disorder:

In children, if necessary, the dose must be determined by the physician. In adults, a 50 mg dose should be ingested on the first night, which can subsequently be adjusted but should not exceed 300 mg per day.

Manic (Bipolar Disorder):

In children between the ages of 10 - 17, a 50 mg per day starting dose to be consumed in the evening is sufficient. However, the dose can be adjusted. The safety of Seroquel in children below ten years has not been established.

Major Depression Disorder:

50mg per day in the evening, not exceeding a total of 300 mg, is adequate.


Before consuming Seroquel, do well to inform your physician if you have had any recent history of:

  • Hyperlipidemia

  • Hyperprolactinemia

  • Thyroid disorders

  • Hepatic disorders

  • Kidney disorders

  • Heart attacks, stroke, or other cardiovascular disorders

  • Leucopenia ( neutropenia)

  • Cataracts

  • Difficulty in swallowing

  • Hypotension or hypertension

  • Seizures or epilepsy

  • Diabetes

Contraindication and Side Effects of Seroquel

This drug is contraindicated in people who have hypersensitivity to any of its active ingredients or other components. Inform your doctor about your allergy history before choosing Seroquel.

Some side effects associated with the drug include:

  • Unusual drowsiness accompanied by sleepiness

  • Cold sweats

  • Dizziness or lightheadedness

  • Chills

  • Blurred vision

  • Coughs

  • Inability to move the eye

  • Inability to sit still

  • Loss of balance control

  • Puckering of the lips

  • Changes in speech patterns and rhythms

  • Pains during urination

  • Drooling

  • Loss of balance

  • Restlessness

  • Sore throats

  • Difficulty in breathing

  • Difficulty in speaking

  • Difficulty while swallowing

  • Cheeks puffing

  • Increased eyelid spasms

  • dark and or tarry stools.

  • Shakiness of the upper and lower limbs

  • Bradycardia


Seroquel interacts with different drugs, disease conditions, and compounds. Only a few drug interactions are listed here.

It interacts with ketoconazole and other Cytochrome (CYP3A4)  inhibitor-containing drugs. Also, it interacts with Carbamazepine, phenytoin, and other conventional antipsychotic medications like haloperidol.

Other drugs interactions include:

  • Lisinopril

  • Tramadol

  • Omeprazole

  • Zoloft

  • Lexapro

  • Cholecalciferol and

  • Metformin

Seroquel interacts with ethanol, potentiating its cognitive and motor effects. Therefore, you should avoid consuming it with alcohol.

Additionally, the drug interacts with the following disease conditions:

  • Hypotension

  • Hypothyroidism (thyroid hypofunction conditions)

  • Liver diseases and other conditions that are associated with elevations in Alanine aminotransferases

  • Obesity or other conditions that lead to weight gain.

  • Dyslipidemias (hypercholesterolemia and hypertriglyceridemia)

  • Acute alcohol toxicity

  • Hypertension (causing both increases in diastolic and systolic blood pressure)

  • Priapism

  • Parkinson's disease

  • Hyperprolactinemia

  • Seizures

  • Tardive dyskinesia, which is characterized by involuntary movement of facial and jaw muscles

  • Suicidality (having suicidal thoughts or ideations)

  • Cataracts

  • Diabetes (hyperglycemic conditions)

  • Central nervous system depression

  • Long QT syndrome (a condition characterized by fast and chaotic heartbeats)

  • Neuroleptic Malignant Syndrome

Missed Dose and Overdose

Once you miss any dose, take it as soon as you can remember. It is, however, more appropriate to skip a missed dose if you discovered it just close to the time you are meant to take the next dose. Inform your doctor about missed doses.

Also, if you suspect Seroquel overdose, call the poison control center in your area.


Seroquel should be stored at room temperature, away from light and moisture, and out of the reach of children and pets.